Cut-Off Levels of Anti-Mullerian Hormone for The Prediction of Ovarian Response, In Vitro Fertilization Outcome and Ovarian Hyperstimulation Syndrome

Authors

  • Ali Salmassi Department of Gynaecology and Obstetrics, Center of Reproductive Medicine, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany
  • Andreas Gerd Schmutzler Department of Gynaecology and Obstetrics, Center of Reproductive Medicine, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany
  • Anupama Deenadayal Department of Gynaecology and Obstetrics, Center of Reproductive Medicine, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany
  • Christel Eckmann-Scholz Department of Gynaecology and Obstetrics, Center of Reproductive Medicine, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany
  • Jurgen Hedderich Institute of Medical Informatics and Statistics, University of Kiel, Kiel, Germany
  • Liselotte Mettler Department of Gynaecology and Obstetrics, Center of Reproductive Medicine, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany
  • Soeren von Otte Department of Gynaecology and Obstetrics, Center of Reproductive Medicine, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany
  • Walter Jonat Department of Gynaecology and Obstetrics, Center of Reproductive Medicine, University Hospitals Schleswig-Holstein, Campus Kiel, Kiel, Germany
Abstract:

Background Evaluation of anti-mullerian hormone (AMH) cut-off levels in assisted reproductive technology (ART) as predictive factor for individualization of stimulation protocols and to avoid ovarian hyperstimulation syndrome (OHSS). MaterialsAndMethods In a retrospective study, 177 infertile patients were assessed for AMH in serum and follicular fluid (FF) on the day of follicular puncture (FP), between 2012 and 2013 in Kiel, Germany. AMH levels and pregnancy rates were compared between low, moderate and high responders and cut-off levels of low and high responders. AMH cut-off levels in pathological cases were evaluated in analysis 1 (OHSS) and in analysis 2 [polycystic ovarian syndrome, (PCOS)] and compared in analysis 3 to normal endocrinological parameters. Results AMH levels in FF were higher than in serum (P

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cut-off levels of anti-mullerian hormone for the prediction of ovarian response, in vitro fertilization outcome and ovarian hyperstimulation syndrome

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volume 9  issue 2

pages  157- 167

publication date 2015-07-01

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